VEXAS is a rare, chronic autoinflammatory syndrome with currently no approved treatments. 

Myelofibrosis is a rare blood cancer that affects the bone marrow. It causes scar tissue to form, and as this builds up, it disrupts the body’s normal production of blood cells. This can lead to symptoms like fatigue, weakness, and an enlarged spleen.

Thrombocytopenia is a condition where the platelet count in the blood is too low. Platelets, also known as thrombocytes, play an important role in blood clotting and help prevent bleeding. 
 

DLBCL is a form of non-Hodgkin lymphoma and the most common blood cancer. Lymphomas occur when cells of the immune system, known as B lymphocytes, grow and multiply uncontrollably. DLBCL occurs mostly in adults and is a fast-growing (aggressive) lymphoma.

Second-line treatment: treatment for a disease or condition after the initial treatment (first-line treatment) has failed, stopped working, or has side effects that aren't tolerated.

In collaboration with ADC Therapeutics SA.